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As mtROS production increases, the components of the respiratory chain and enzymes of the Krebs cycle are inactivated, leading to cell structure damage [22]

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Since diagnosis, the median (range) duration of the disease, motor fluctuations and dyskinesia was 7.9 years (3.7–12.2 years), 4.3 years (1.2–8.3 years) and 2.4 years (0.2–5.3 years), respectively, with very high dopa sensitivity (median: 78.9%